Endocrine Abstracts

In the last 50 years survival after childhood cancer has dramatically improved. However, childhood cancer survivors (CCS) are at risk for a considerable array of late effects arising from previous anti-cancer therapies. The excess mortality (compared with the general population) in CCS is mostly due to second neoplasms and cardiovascular diseases. Indeed, the cardiovascular system has been recognized as a highly sensitive target for damage by anti-cancer therapies. Early in th...

Cardiovascular (CV) diseases significantly contribute to the mortality excess observed in survivors of pediatric acute lymphoblastic leukemia (ALL) who received hematopoietic stem cell transplantation (HSCT). The study explores advanced glycation end-products (AGEs) levels, inflammatory status and lipid profile in a cohort of ALL survivors, in order to investigate their potential role in the pathogenesis of CV late effects. Inclusion criteria were: a) previous diagnosis of ALL...

IntroductionPrimary hypothyroidism, which is one of the main endocrine complications of allogenic stem cells transplantation (allo-SCT), has been largely studied in children. Conversely, data on adults are still limited with a reported incidence widely ranging between 9 and 47%. Older age, multiple allo-SCT, chronic Graft vs Host Disease (cGVHD), prolonged immunosuppressive therapy and high-dose total body irradiation (TBI) have been indicated as potenti...